An experimental study of the hebavioral effects of carbethoxysyringoyl methylreserpate (singoserp).

Physiological studies and preliminary behavioral screening with animals have indicated that syrosingopinel (carbethoxysyringoyl methylreserpate) , a reserpine derivative, is a hypotensive drug with little or no “tranquilizing” action. The present study was designed to explore and check on these findings, as related to adverse behavioral effects, in a controlled experiment with human patients. The Driver Trainer and Ortho-Rater, used in previous experiments (Marquis et al., 1957; Kelly et al., 1958b) to test for possible adverse behavioral effects of psychoactive drugs were employed to test the effects of syrosingopine on psychomotor and visual functions. Simple tests of attention, alertness, tempo, and mood were used to explore some of the other common modes of action of a psychoactive drug. METHOD